Thermo Fisher Scientific has announced that the Maybridge Ro3 Diversity Fragment Library is now available in a prepared format for time-efficient drug discovery lead generation.
Each compound in the library is pre-dissolved as a DMSO solution.
The Maybridge Ro3 Diversity Fragment Library contains a range of 1,500 compounds, many of which are small-molecule pharmacophores available only from Maybridge.
Manufactured and selected specifically to meet 'Rule of Three' requirements, these fragments are a suitable first step in pharmaceutical lead development.
The ready-to-use format offers user convenience, saving time on sample and stock solution preparation.
Available in three 500-compound sets, each compound in the library is pre-solubilised as a 1ml 10mM solution, providing 10uMol of 95 per cent purity pharmacophore dissolved in analytical-grade DMSO.
The libraries are also available at higher concentrations upon request to meet specific customer needs.
The Maybridge Ro3 Diversity Fragment Library is provided in standard, automation-compatible, matrix tube and latch-rack formats and is also available pre-packaged to fit any standard microplate footprint, with cap mat seals for automated, high-throughput applications.
Each compound has a Tanimoto similarity index of 0.66, allowing for good structural diversity across the library.
The library contains a large number of compound fragments that are linker friendly, enabling them to be incorporated into larger drug molecule backbones.
