Gilson has expanded its HPLC purification range with a new LC/MS system that enables researchers to use the specificity of mass spectrometry to improve their purification processes.
The addition of a mass spectrometer allows mass-targeted purification and thus reduces the number of collected fractions to be processed while providing information on the mass of purified compounds.
The new LC/MS purification system features an MS detector combined with Gilson's preparative HPLC system to produce a usable mass-targeted purification system.
The Gilson LC/MS system is claimed to be easy to use and has been developed around the existing Trilution LC software dedicated to preparative chromatography and the GX-271/GX-281 injection/collection platforms recognised for their robustness and flexibility.
The Flexar SQ 300 mass spectrometer is a single quadrupole detector with a wide mass range (50-3,000amu) and a fast scanning speed (10,000amu/sec), making it suitable for a number of chemical compounds and fast enough for the precise fraction collection associated with all Gilson preparative HPLC systems.
Robust and simple to clean, the source has been designed for the needs of the preparative chromatographer with an adjustable spray.
The mass spectrometer is fully integrated in Trilution LC, a software system that gives users full control of injection and fraction collection.
The fraction collection can be performed based on a combination of signals from UV/Vis, ELS and up to seven MS channels, each of which may be set to a mass range or a targeted mass.
The large range dynamic splitter allows the implementation of this new MS detection to the entire range of Gilson purification systems, from analytical, semi-preparative and preparative up to 200ml/min.