Moulder Center for Drug Discovery Research at Temple University has selected Thermo Fisher Scientific's Maybridge screening libraries to identify compounds that might be useful in treating illnesses.
Thermo Fisher will provide the Moulder Center with a custom compound library based initially on the 14,000-strong Hitfinder collection.
This library will be used within the university, as well as by its continually expanding list of academic, pharmaceutical and biotechnology partners.
The centre's studies are currently focused on the identification of compounds targeting drug addiction and withdrawal symptoms, as well as the development of Alzheimer's disease.
Each is built on a foundation of rational design that is based on Lipinski's Rule of Five, which utilises both computer-aided analysis and high-throughput screening assays.
With an expanded Maybridge Hitfinder library of more than 20,000 candidate molecules, the team at the Moulder Center hopes to screen a wide range of compounds.
In addition to conducting its own research, the Moulder Center collaborates with many research partners, using its knowledge and resources to expand their drug discovery pipelines.
The Maybridge Hitfinder collection is a premier offering of drug-like screening compounds that uses an industry-standard clustering algorithm to select a statistically representative sample of the full collection.
All compounds have purity greater than 90 per cent and have been selected to be non-reactive, ensuring fewer false positives and higher-quality results.
