Thermo Fisher Scientific has introduced its triple quadrupole liquid chromatography-mass spectrometry (LC-MS) platform.
The platform, which includes the Thermo Scientific Quantiva triple-stage quadrupole mass spectrometer and the Endura triple-stage quadrupole mass spectrometer, was showcased at the ASMS Conference on Mass Spectrometry and Allied Topics in Minneapolis.
“Evolving applications continue to push the limits of instrument performance,” said Iain Mylchreest, vice president of research and development, chromatography and mass spectrometry, Thermo Fisher Scientific.
“We have created a completely new instrument platform, built from the ground up, to deliver extreme sensitivity and uptime,” he added.
The TSQ Quantiva triple quadrupole mass spectrometer employs Active Ion Management (AIM) to optimise ion creation and transmission from the source to the detector, resulting in extreme sensitivity.
This enhanced level of sensitivity greatly improves results in applications such as peptide quantitation, metabolomics and biopharmaceutical QA/QC compared to previous Thermo Fisher triple quads.
In company laboratories, AIM-enhanced systems have measured 70 attograms of verapamil in plasma on column with excellent precision, an unprecedented level of performance.
TSQ Quantiva MS system is able to perform 500 SRM experiments per second, and positive/negative polarity switching in 20ms with no signal loss.
The TSQ Quantiva MS has been shown using synthetic serum stress tests to operate approximately three times longer between maintenance intervals than the company’s previous best systems, without loss of signal.
The TSQ Endura triple quadrupole mass spectrometer was designed to deliver higher uptime than any competitive triple quadrupole instrument.
Both are designed for plug-and-play exchange between each other.
Gas and electrical connections are made automatically when sources are installed, and ESI, APCI, and nanospray housings and probes are automatically recognised by the system.
Additionally, method parameters can automatically pass between systems to support discovery and verification studies employing both instruments.