GE Healthcare has launched its Capto S ImpAct cation exchange chromatography medium for efficient and flexible purification of monoclonal antibodies (MAbs).
According to GE, Capto S ImpAct is a strong cation exchanger for the intermediate and polishing steps when purifying MAbs and a wide range of other biomolecules.
Part of the Capto platform of high-performance chromatography media, Capto S ImpAct is designed to offer both high binding capacity and high resolution at high sample loads.
The high-flow characteristics of the Capto base matrix enables superior pressure-flow properties.
Moreover, the small bead size for high resolution, in combination with the novel extended-surface ligands, supports high dynamic binding capacity at high sample loads.
The ability to run at both high flow rates and bed heights combines with these attributes to increase productivity and flexibility in process design.
Capto S ImpAct is delivered in different bulk sizes as well as in many pre-packed formats such as PreDictor 96-well filter plates, PreDictor RoboColumn, HiTrap, and HiScreen columns.
Features overview:
- High binding capacity, more than 100 mg MAb/mL medium
- High-resolution for efficient aggregate removal at high sample loads
- Large operational window of flow rates and bed heights for easy optimisation and scale up
- High productivity, enabling cost-efficient manufacturing
- Security of supply and comprehensive regulatory support
