Genevac has developed a suite of proprietary technological solutions to facilitate post purification sample handling, including reformatting.
Labs undertaking purification using Normal Phase HPLC, SFC or Flash chromatography can simply and safely remove organic solvents using a Genevac centrifugal evaporator (EZ-2, ROCKET, Rocket Synergy or HT Series III).
The company’s DriPure technology is designed to completely eliminate the problem of solvent bumping that can occur with some samples.
The evaporation of aqueous acetonitrile (or methanol / ethanol) fractions resulting from Reverse Phase HPLC is a widely carried out application on many Genevac evaporator systems.
A multiple stage method has been developed for the EZ-2 evaporator to remove the organic solvent without freezing the water, remove the water, and then dry any remaining stubborn solvent.
Alternatively, the LyoSpeed fast lyophilisation method in Genevac HT series evaporators can be used to produce dry (solvent-free) powders from samples that could once only be produced as gums and oils.
Advances in condenser technology, in particular the high power -75°C cold trap, available on HT Series III and Rocket Synergy evaporators, has led to significant advances in lyophilisation success rates.
Post purification, samples typically need to be reformatted from fraction tubes or flasks into a small vial for compound storage. SampleGenie enables a large volume to be dried (or lyophilised) directly into a small storage vial in a fraction of the time taken by traditional evaporation methods that require users to reformat samples from a flask or multiple tubes into a vial.
