Revolutionary system can sensitively, rapidly and economically detect analytes in complex fluids such as serum without the need for radio-, enzymatic or fluorescent labels
Acoustic technology granted US patent Revolutionary system can
sensitively, rapidly and economically detect analytes in complex
fluids such as serum without the need for the radio-, enzymatic
or fluorescent labels used currently.
Akubio, an acoustic
detection technology company, reports that its patent for its
core rupture event scanning (Revs) technology for the detection
and separation of molecules has been granted by the US patent
The patent, number USP 6589727, was granted on 8 July
Commenting on the patent, John Pritchard, CEO, said:
"Revs technology has significant advantages over existing
technologies: it can sensitively, rapidly and economically detect
analytes in complex fluids such as serum without the need for the
radio-, enzymatic or fluorescent labels used currently.
granting of our first patent puts Akubio in a strong position to
commercialise the technology for applications in the life science
research and in vitro diagnostic markets".
Revs is one of
two revolutionary acoustic technologies being developed by
It can be used to size, separate and detect ligands.
technique works by effectively shaking the ligand, such as a
virus particle, off a vibrating surface, at present a quartz
The acoustic energy, or sound, generated when
interactions between the ligand and its receptor are broken is
then detected by using the resonator as a very sensitive
More strongly attached ligands detach at larger
amplitudes of oscillation, so that separation and detection are
performed in the same experiment.
The magnitude of acoustic
energy (ie the loudness of the sound) is proportional to the
number of ligands on the surface, making the technique fully
Revs has the potential to be used in a wide range
of applications including human and veterinary diagnostics, drug
discovery, life sciences research, bioterrorism, food testing and
environmental monitoring and in process monitoring of production
The core component used for detection (a quartz
resonator) is employed in many electronic devices, eg watches and
computers, and is mass-produced in the billions.