During process development, several steps can be affected by the characteristics of crystals, and understanding how and when crystals are formed is vital to downstream processes
Today there is increasing pressure to manufacture active pharmaceutical ingredients with the right formulation behaviour and a robust physical structure, says Mettler Toledo.
During process development, several steps can be affected by the characteristics of crystals, and understanding how and when crystals are formed is vital to downstream processing operations such as filtration and drying.
Focus beam reflectance measurement (FBRM) and particle vision measurement (PVM) are ideal for characterising, in real-time, processes in the laboratory and production plant.
The FBRM probe provides information on crystal size and number while PVM technology allows direct particle visualisation.
In addition a range of automated laboratory reactors enable process parameters to be accurately controlled and optimised.
