Encompassing over 90% of the Drosophila genome, researchers can study the function of specific genes through genome-wide screens - a first step in shedding new light on disease processes
MRC Geneservice has announced the launch of its extensive new Drosophila RNA interference (RNAi) library.
Encompassing over 90% of the Drosophila genome, researchers can study the function of specific genes through genome-wide screens - a first step in shedding new light on disease processes and possible drug targets.
Covering over 13,600 genes, the new Drosophila RNAi library complements the extensive Caenorhabditis elegans RNAi library and allows MRC geneservice to offer access to 'whole genome' RNAi libraries of the two main model organisms used in functional genomic studies.
The C elegans RNAi library has been successfully distributed to many laboratories over the world and has led to many important published discoveries.
Both RNAi libraries are available through the MRC geneservice website.
Tom Weaver, chief executive of MRC Geneservice said: "By enabling systematic screening of gene function, RNAi technology is the focus of a great deal of scientific endeavour and we feel that it will play an increasingly vital role in both academic and commercial research over the coming years".
The RNAi mechanism in Drosophila is similar to C elegans allowing processing of long double-stranded RNAs (dsRNAs) into short small interfering RNAs (siRNAs) when transferred into living cells.
As Dr Weaver explained, "This method of silencing genes is far more cost-effective than using chemically synthesised siRNAs or a vector-based strategy.
"Coupled with our high throughput production this means that we offer researchers exceptional value for money".
MRC geneservice manufactures the Drosophila RNAi constructs from the original library developed by Cyclacel, under strict quality control conditions with full validation by gel analysis and RNA synthesis.
These are provided with complete information on the genes and primer sequences and can be ordered online with extremely fast turnaround.
As a service provider, MRC geneservice also offers researchers an optional custom dsRNA production service for specific requirements.
