Unveiled at LabAutomation 2004, this mPLC system increases sample analysis capacity by enabling 24 simultaneous separations
Nanostream, provider of high-throughput microfluidic analytical systems to companies involved in drug discovery and development, announces the release of its premier product, the Veloce micro parallel liquid chromatography (mPLC) system.
The Veloce system is designed to deliver increased sample analysis capacity to scientists that need information to make timely research decisions.
Nanostream developed the Veloce system after extensive market research revealed an unmet need for faster and higher quality sample analysis in analytical chemistry, specifically in the drug discovery and development process.
The Veloce system uses established HPLC techniques and integrates with conventional laboratory workflow to increase time and cost efficiency. "After surveying leading pharmaceutical companies, we realised that the demand for higher analytical throughput has increased significantly over the last decade.
"We designed the Veloce system for scientists who need to analyze more samples in less time," said Stephen O'Connor, CEO of Nanostream.
"Our system provides an ideal platform to accelerate assessment of compound purity, stability and other physicochemical properties for a large number of compounds". The benefits of the Veloce system include increased sample analysis capacity and the ability to generate chromatograms comparable to conventional HPLC instrumentation for a broad class of analytical chemistry applications.
The Veloce system enables 24 simultaneous separations and real-time UV detection, allowing analysis of more samples in less time.
This parallel analysis provides the ability to analyse a large number of compounds, increase the number of replicates or conditions used in a study and reduce solvent consumption and mixed waste generation.
At the heart of the Veloce system is the 24-column Brio cartridge, which enables multiple samples to be analysed in parallel for increased throughput.
The Brio cartridge, made of polymeric materials, incorporates 24 columns packed with standard (C-18) stationary phase material to achieve reverse phase separations.
Cartridges can be selected to fulfill throughput and to optimise performance for specific experimental protocols.
"Nanostream's parallel format increases sample analysis capacity without compromising the quality of the data," said Mike Lee, president of Milestone Development Services, which pioneered the application of LC/MS in different phases of drug development. "The Veloce system easily outpaces the throughput achieved by conventional, serial HPLC, and the user-friendly format makes it attractive to scientists who conduct high-volume, routine analyses".
Because the Veloce system incorporates established HPLC techniques, scientists can continue to use existing processes and methods when adopting this product. Initially optimised for analytical chemistry applications in drug discovery and development, the Veloce system is ideal for applications that would most benefit from faster throughput. Nanostream is committed to expanding the Veloce system platform with additional features and software enhancements to address a broader set of analytical chemistry applications.
In addition to UV absorbance, the system is being designed to permit detection using various modes, including fluorescence.
