High-throughput microfluidic analytical system provides platform for compound purity, solubility and separation-based assays
Scientists at Nanostream, a provider of high-throughput microfluidic analytical systems to companies involved in drug discovery and development, are presenting new applications for its Veloce micro parallel liquid chromatography system during the SBS 10th conference and exhibition.
High-throughput screening researchers know that poor compound purity or solubility dramatically affect the outcome of an assay.
To date, Nanostream has proven the utility of its Veloce system for compound purity and physicochemical property screening.
During SBS, Nanostream will present two high-throughput approaches to assess thermodynamic solubility.
One approach with the Veloce system employs sonication while the other uses filter plates. Nanostream's Veloce system provides an ideal format for separation-based assays.
Separation-based assays performed using liquid chromatography (LC) offer certain advantages when compared to assays performed using plate-readers or CE.
At SBS, Nanostream will also present data to show how the Veloce system has been used for a number of assays, by showing results for enzyme kinetics and IC50 curves.
