Troubleshooting background peaks in a chromatographic run can be a time-consuming and challenging proposition
For gradient high performance liquid chromatography (HPLC) methods, minute contamination of the mobile phase during normal preparation can compromise the baseline quality and chromatographic data significantly.
A recently published article entitled 'Mobile phase cleanup using solid phase extraction disks' is available from Presearch.
The authors describe a fast, simple procedure for purifying mobile phase that uses solid phase extraction disks during the filtration step for mobile-phase preparation.
The procedure removed more than 95% of contaminants, so it is effective and suitable for various gradient HPLC methods.
