2004 Nobel Prize in chemistry awarded to Sigma-RBI collaborator Aaron Ciechanover, with Avram Hershko and Irwin Rose, for the discovery of ubiquitin-mediated protein degradation
Sigma-RBI has sent congratulations to the 2004 Nobel laureates in chemistry, Avram Hershko, Irwin Rose, and Sigma-RBI collaborator Aaron Ciechanover.
Their research led to the realisation that protein degradation is a highly controlled process involving the attachment of the molecule ubiquitin to unwanted proteins to mark them for disposal.
Failure of this system has been implicated in such diseases as cervical cancer and cystic fibrosis.
Sigma-RBI says it is especially proud of its association with Ciechanover, who in September 2003 authored an article entitled 'The Ubiquitin-Proteasome System: Death of Proteins is Required for Life of Cells' for the division's quarterly Celltransmissions cell signaling newsletter.
Dr Ciechanover is currently director of the Rappaport Family Institute for Research in Medical Sciences at the Technion (Israel Institute of Technology) in Haifa, Israel.
"We feel honoured to be able to include Dr Ciechanover among our Celltransmissions authors," stated Keith Watling, director of Sigma-RBI. "His landmark discoveries, together with Drs Hershko and Rose, have provided critical insight into how proteins are degraded and disposed of inside the cell".
Sigma-RBI is the leading supplier of products for ubiquitin-proteasome and cell stress research.
Its product line includes ubiquitin proteins, inhibitors and antibodies, proteosome fractions and range of enzymes, inhibitors and antibodies for nitric oxide, cell stress, and protein degradation research.
