Products enable life scientists and analytical chemists to optimise resolution and throughput, and to improve reproducibility in capillary and microchannel electrophoretic separations
Target Discovery, a discovery biology company, has announced the launch of its EOTrol suite of dynamic coating reagents for electrophoretic separations.
The EOTrol line of products enables life scientists and analytical chemists to optimise resolution and throughput, and to improve reproducibility in capillary and microchannel electrophoretic separations.
Certain formulations in the EOTrol family also expand the range of electrophoretic separations that can be conducted in these analytical formats, addressing previously unattainable separations.
"The EOTrol product line is the first of several upcoming product offerings, all aimed at overcoming significant current technical limitations in critical biological research and discovery technologies," said Target Discovery CEO Jeffrey Peterson.
"Target Discovery's new platform technologies are designed to enable researchers to collect the kind of comprehensive, high-quality bioinformation that they need to achieve new levels of effectiveness in developing and corroborating systems biology models of biological pathways.
"Target Discovery believes this integrated 'omics to knowmics' strategy and the resulting confirmed understanding of biological pathways is the key to breaking the spiral of increasing drug development and healthcare costs that have challenged our industry and our economy for the last four decades.
"We continue to execute our near-term business objectives by bringing these innovative technologies to market, with the overall goal of contributing to a new era in productivity for life science research".
The uncontrolled EOF exhibited by uncoated capillaries has substantially limited the number and types of analytes that can be effectively separated.
The non-uniformity of EOF in coated capillaries available today results in significant peak broadening and lower resolution separations.
The EOTrol line of dynamic coatings provides user-selectable alternatives for electroosmotic flow (EOF) that are independent of pH and buffer choice, breaking through frustrating limitations in the applicable range, complexity, resolution and throughput of current electrophoretic methods.
EOTrol technology enables the full horizon of anion and cation separations and is an important component in Target Discovery's development of a proprietary multidimensional capillary electrophoresis technology that enables full-proteome level separations, eclipsing the limitations of today's methods in expressional proteomics. Three reagents are initially offered from the EOTrol family, providing consistent and reproducible High Normal (normal EOF level and flow direction), Low Normal (low EOF that is more resilient and consistent than the best coated capillaries) and High Reverse (opening up a whole new class of separations through reversal of EOF direction) with others to follow.
EOTrol coatings may be removed with a simple strip procedure, allowing the same capillary to be used with multiple EOTrol formulations and rapidly converted to widely differing applications without capillary removal or replacement.
Compatible with any commercially available or homemade capillary electrophoresis system, EOTrol dynamic coatings may be ordered through Target Discovery's website.
"Capillary electrophoresis has never realised its potential for discovery biology, due in large part to the limitations imposed by uncontrolled electroosmotic flow.
"With EOTrol dynamic coatings, researchers can independently select the combination of EOF, pH and buffer that is needed to effect both high resolution and time-efficient separations, including suppression or even reversal of EOF," said Luke Schneider, chief scientific officer of Target Discovery.
"While this goal has been the subject of significant research interest, no commercial products have previously provided the necessary tunable and reproducible control over this critical electrophoretic phenomenon."
