Obtaining accurate dissolution data during early-phase discovery/development is now possible using the uDiss ultra-small volume dissolution apparatus
The uDiss is said to be ideal for characterising intrinsic dissolution where the active pharmaceutical ingredient is not available in large quantities.
Using in situ fibre optic UV measurements in volumes as small as 2ml, the uDiss can generate detailed dissolution profiles in minutes.
No removal of the sample during measurement is required.
Up to six vessels can be studies simultaneously.
Each of the six channels of the uDiss apparatus has a dedicated photodiode array detector for fast, whole spectrum UV data.
Two options are available: micro, for volumes from 5ml to 20ml; and ultra-micro, for volumes from 2ml to 4ml.
Currently the uDiss instrument can be used to rank-order compounds by intrinsic dissolution, to detect polymorphic changes, and to follow stability-time profiles.
The uDiss is distributed in central Europe via Heath Scientific.
Technical application notes can be downloaded from the company's website.
