Sub Ambient Synthesis of Novel Gold Organometallic Complexes
30 Jul 2020
Asynt’s DrySyn SnowStorm Reactor and DrySyn Splitter Manifold have been used by researchers at the School of Chemistry at the University of Bristol for the synthesis of novel Gold (Au) organometallic complexes.
Researchers were seeking to create new Au(I) organometallic complexes for use in gold-mediated cross-coupling reactions. Subsequent transmetallation with an organozinc reagent and reductive elimination led to the formation of products with new C-C bonds. The use of gold in these transformations has been shown to offer advantages over the traditionally used Palladium (Pd(0)/Pd(II)), including increased biocompatibility, improved functional group tolerance and better price stability.
During research it was discovered that the success of the transmetallation step was highly dependent on the temperature at which it was undertaken. The DrySyn SnowStorm Reactor fitted with DrySyn vial inserts enabled the researchers to performing up to 12 low temperature reactions in parallel at a reliable and consistent temperature. By connecting the Reactor to a DrySyn Splitter Manifold, the group was able to utilise the recirculating chiller with other equipment in the lab, maximising their use of resources.
Jamie Cadge, a PhD researcher in the Russell Group at the University of Bristol School of Chemistry said: "Synthesis of gold complexes and performing multiple gold-mediated cross-coupling reactions is challenging chemistry. We found that certain steps required stable, low temperatures to be successful. Making use of three vial inserts in the SnowStorm Reactor meant that we could perform multiple reactions at the same time. Consequently, we are able to screen varying conditions for these cross-couplings with different substrates.
“The recirculating chiller unit and manifold supplied with the DrySyn SnowStorm allowed us to improve the environmental impact of our lab as we are no longer reliant on the use of multiple condensers which use tap water or dry ice-cold fingers. I would recommend the DrySyn SnowStorm Reactor to other researchers as it enables multiple reactions to be reliably performed at consistent low temperatures in parallel."
The DrySyn SnowStorm Reactor from Asynt is suitable for scientists seeking to undertake low-temperature chemical reactions and studies (-30 to +150 °C). Prolonged temperature control on the DrySyn SnowStorm is regulated by an external thermostatic circulator. This not only eliminates the risk of temperature fluctuations due to perishable coolants but can also improve a lab’s sustainable use of resources.