All Hugo Sachs Elektronik dedicated isolated heart systems allow on-line transition between langendorff and working heart perfusion
While the long-standing Langendorff (LH) mode of isolated heart perfusion has indisputable utility as a cardiac research tool, it is becoming increasingly clear that many desirable assays require the ejecting capability of an organ perfused in the working heart (WH) mode.
Inarguably, a more physiologically relevant configuration, WH mode provides the ability to monitor the activity of a heart performing pressure-volume work.
A defining characteristic of all Hugo Sachs Elektronik dedicated isolated heart systems is the ability to switch between LH and WH operation, online, in the same heart, with just a few simple manipulations.
In addition, both modes can be maintained using either constant flow or constant pressure perfusion.
Furthermore, physiological cardiac afterload is maintained using an exclusive, patented flow resistance and compliance chamber.
These advanced features and forward-looking design are available in research platforms optimised for all commonly used mammalian research models.
