TargetAnalysis application software for multi-target compound screening in complex matrices provides much increased specificity and enhanced SigmaFit molecular formula determination
TargetAnalysis is a library-based screening software solution able to screen hundreds of compounds from a single sample LC/ESI-Tof run with the ultra stable outstanding mass accuracy provided by Bruker's Microtof or Microtof-Q mass spectrometers.
Using Bruker's unique ESI-Tof technology with intrinsically outstanding mass accuracy and excellent stability over time, over concentration changes during an LC-run, as well as over a wide mass range, scientists can now screen for large compound libraries with a confidence level and reproducibility unsurpassed by any other system.
In contrast to traditional triple- quadrupole mass spectrometers which are limited in the number of targets they can screen per LC run, the Microtof TargetAnalysis solution can easily handle several hundred compounds in a single LC run.
This easy and robust workflow saves significant time when running multi-target applications like drugs/metabolites in urine, food safety analysis, forensic toxicology or environmental testing.
Ian Sanders, executive vice president of Bruker Daltonics, commented: "With the launch of TargetAnalysis, Bruker Daltonics opens up an exciting application area for our unique ESI-Tof Microtof and Microtof-Q systems.
"With this novel screening software, our customers can now automatically create their own application-specific accurate mass libraries, for example, for pesticides in food or in doping control.
"Our unique Amic (accurate mass ion chromatogram) technique, with a tolerance down to +/-0.002Da, dramatically reduces chemical background interference and greatly improves specificity.
"In addition, retrospective in silico screening for new or unexpected compounds is possible because unlike in triple- quad based MRM methods, we retain the full molecular information content in addition to the target library specific information."
