This new product allows the automatic detection of micronuclei formation, providing scientists with a more productive method for screening compounds earlier in the drug-discovery process
The Micronucleus BioApplication relies on the Thermo Scientific Cellomics ArrayScan VTI system, which comprises high-content screening instrumentation, informatics and reagent products, allowing researchers to more rapidly test multiple compounds to discover potential toxic effects on genetic material.
This application provides a more reproducible, method for compound screening at substantially lower labor costs than traditional manual approaches to micronuclei quantification.
Micronucleus formation is a strong indicator of genetic toxicity caused by drug-candidate compounds or environmental toxins.
Existing in vitro assays for micronuclei induction are time-consuming, labour-intensive (requiring several trained personnel) and can be subjective.
Because of these constraints, it has been virtually impossible to efficiently test large numbers of compounds for this important indicator of genotoxicity.
With the launch of the new Cellomics Micronucleus v3.0 BioApplication, more cell lines can be tested with more industry standard assay configurations.
This flexibility enables screening for indicators of genetic toxicity earlier in the development of therapeutic candidates and improves attrition rates, increasing efficiency and significantly reducing costs for pharmaceutical companies.
