Agilent Technologies has released a HPLC-Chip that simplifies the analysis of phosphopeptides in proteomics research.
The Phosphochip is used with Agilent HPLC-Chip/MS instrumentation to identify post-translational modifications (PTMs) as part of regulating biological pathways.
This HPLC-Chip was co-developed with Prof Albert JR Heck's group at Utrecht University as part of the Netherlands Proteomics Centre research programme.
Agilent's Phosphochip combines enrichment and analysis of phosphopeptides into a single-step LC/MS analysis when used with the Agilent HPLC-Chip/MS interface and Agilent 6000 Series mass spectrometers.
The HPLC-Chip has an integrated microfluidic design that enables routine PTM analysis.
Protein phosphorylation is one of the most important PTM events within mechanisms that regulate protein function in biological cells.
Agilent now offers 12 versions of HPLC-Chips.
All Agilent HPLC-Chips are compatible across the entire portfolio of Agilent mass spectrometers for applications that include peptide quantitation, biomarker discovery, targeted phosphopeptide analysis, glycan and monoclonal antibody characterisation, and small molecule DMPK studies.
Agilent's custom chip programme delivers customised solutions to individual needs.
