Febit has announced the launch of a biochip covering the whole mouse genome for DNA/RNA detection and enrichment.
The biochip from Febit enables up-to-date profiling and enrichment of genes and SNPs of interest using gene expression profiling, SNP-detection, ncRNA analysis as well as targeted enrichment of genes for next-generation sequencing (NGS).
In the near future, NGS technologies will lead to a rising number of completed genomes of model organisms and other species of interest, as demonstrated by the updated mouse genome.
This accelerated development will generate a variety of tools available in the short term for the application of the new data into experiments.
Febit's Geniom technology is an efficient option for transforming digital genetic sequence information directly into a fully-applicable microarray and sequence capture biochip.
The microfluidic biochips and flexible probe synthesis guarantee instant access to the latest sequence updates just days after publication or request.
The mouse (mus musculus) is the most important and well-established model for the study of human disease and mammalian development.
At the end of May 2009, DM Church et al published in the journal 'PLoS Biology' a complete, high-quality genome assembly that contains more than 139 Mb more of novel sequence compared with previously available mouse genome drafts.
This finished mouse genome, which is now available on Febit's microarrays, closes more than 175,000 gaps, completes the list of protein-coding genes to a number of 20,210 and identifies 439 long, non-coding RNAs.
Therefore, a complete analysis of protein gene expression, microRNA profiles and expression patterns of long non-coding RNAs is possible and can reveal many previously hidden secrets of mammalian biology and disease processes.
Flexibel technology for fast-paced research Febit's Geniom technology provides turnkey solutions with established protocols and streamlined workflows, enabling all major RNA profiling applications as well as targeted NGS.
Hybselect, sequence-specific DNA enrichment is enabled through hybridisation and elution of high-value target regions by utilising Febit's flexible Geniom biochips.
The enriched DNA is ideally suited for cost-effective targeted sequencing on NGS platforms.
With its Hybselect biochip for the mouse genome, Febit complements its offering for up-to-date sequence analyses in the field of mammalian research.
Biochips for other models will follow as soon as the appropriate sequence analyses are completed.
Febit biochips are available for analysis at the Geniom RT Analyser or as a full service from Febit.
