Phenomenex , a manufacturer of separation-science consumables, has introduced the Kinetex LC columns based on the company's core-shell silica technology.
By delivering improvements in speed and separation efficiency over traditional three- and five-micron columns, Kinetex enables chromatographers to get performance comparable to sub-two-micron columns without investing in UHPLC systems.
With Kinetex, researchers can achieve UHPLC results on any LC instrument platform, and any chromatographic method can be completed at a fraction of the time previously required, without sacrificing performance.
The increased separation efficiencies of Kinetex also reduce solvent usage and maintain long column life.
Kinetex core-shell technology enables high resolution and sensitivity over an extended linear velocity without generating excessive backpressure.
These columns provide roughly twice the efficiency of fully-porous three-micron columns and three times the efficiency of fully-porous five-micron columns with lower limits of detection and quantitation.
Initially, Kinetex core-shell columns are available in two particle sizes - 2.6- and 1.7-micron, and three chemistries - C18, PFP and HILIC.
Kinetex 2.6-micron columns deliver separation efficiencies that match or exceed the performance of traditional fully-porous sub-two-micron columns.
The Kinetex 1.7-micron delivers efficiency gains of 15 to 20 percent over traditional fully-porous sub-two-micron columns.
Method-transfer challenges, common with traditional sub-two-micron products, are eliminated.
Methods developed with either 2.6- or 1.7-micron Kinetex columns are scalable and can be transferred to any LC system using the 2.6-micron column, regardless of the instrument's pressure capability.
In food-safety applications such as the detection of carbamate pesticides, antibiotics, aflatoxins or azo dyes, Kinetex enables better resolution of more complex mixtures in less time.
The same is true for environmental analyses such as detection of explosives, carbamate pesticides and chlorinated herbicides.
In drug-discovery research and toxicology studies, the speed of Kinetex analysis can reduce development time on therapeutics such as tricyclic antidepressants, sulfa drugs, beta-blockers, ranitidine and cough and cold medicines.
