Sigma-Aldrich has announced a worldwide licensing agreement with Polyplus transfection to manufacture Zip Nucleic Acid (ZNA*) oligonucleotides, enabling increased affinity for nucleic acids.
Under the terms of the license, Sigma-Aldrich has rights to manufacture and commercialise ZNA oligonucleotides for all research applications.
ZNA are oligonucleotides with attached cationic units, offering significant value for a variety of applications in research and diagnostics applications.
Research applications include PCR probes, PCR primers, in-vitro micro-RNA detection and inhibition, and siRNA.
The addition of cationic residues to oligonucleotides increases their sensitivity and their ability to detect mutations, while remaining easy to design.
ZNA also offers an increased affinity for nucleic acids without losing selectivity, improving performance in hybridisation techniques.
