SAFC Biosciences has introduced Ex-cell Antifoam, a non-animal-origin solution that enhances foam control in cell-culture bioreactors for cell-culture manufacturing.
The Ex-cell Antifoam solution is formulated from a 30 per cent simethicone emulsion and validated by a simethicone quantification assay that confirms lot-specific concentration.
This USP Grade non-ionic emulsion (simethicone) is designed for use in the pharmaceutical and veterinary biological industries to aid in the control of cell-culture foaming in bioreactors.
Through formulation optimisation, utilisation of a quantitative assay and understanding the non-specific binding of simethicone, SAFC Biosciences is able to report the actual simethicone concentration of the gamma irradiated finished material, producing a stable end product.
Ex-cell Antifoam is ready to use and should be directly supplemented into culture systems to prevent or eliminate foaming that occurs due to mixing and shear forces.
