Millipore is to introduce Chemibrite Luminescent GPCR Reporter Frozen Cells at the Society of Biomolecular Sciences Annual Meeting on 11-15 April 2010 in Arizona, US.
The cells are claimed to allow drug developers to expand their testing of popular G-protein coupled receptors (GPCRs).
Currently, 40 per cent of all marketed drugs are targeted to GPCRs, indicating their therapeutic importance.
However, because of the limitations of traditional fluorescent GPCR assays, many potentially efficacious compounds have never been tested as GPCR agonists or antagonists.
To overcome this challenge, drug developers are increasingly turning to chemiluminescent GPCR assays.
Chemibrite Frozen Cells offer a non-toxic luminescent readout, in contrast to fluorescence dye-based assays that can cause cell death over time.
In addition, luminescent measurement is not affected by the interfering background 'noise' produced by autofluorescent cells or compounds.
Chemibrite Luminescent GPCR Reporter Cells are provided frozen in a convenient read-to-assay format, so they can be used immediately after thawing.
The cell lines are the latest addition to Millipore's portfolio of GPCR profiling products and services, which includes Chemiscreen GPCR cell lines and the GPCRprofiler service - an outsourced cell-based functional assay service for GPCR profiling.
