Columns from YMC Europe can separate achiral APIs in SFC mode and are suitable for use in a variety of pharmaceutical industry applications, particularly for the purification of enantiomers.
SFC also has a role in analytical separations and the larger-scale purification of achiral compounds as it is seen as an economical and environmentally friendly alternative to classical HPLC.
The use of supercritical CO2 as the main component of the mobile phase reduces the consumption of expensive and environmentally harmful organic solvents.
In SFC mode, an average of about 80 per cent less organic solvent is required than in classical normal-phase HPLC.
Owing to the low viscosity and high diffusibility of the supercritical mobile phase, SFC separations are at least three to five times faster than in classical HPLC, according to the company.
As a result, sample throughput in SFC mode is very high, which reduces the time pressure in the pharmaceutical industry.
YMC-Diol, YMC-Amino, YMC-Cyano, YMC-PVA-Sil, YMC-Polyamine II and YMC-Silica provide a range of different SFC selectivities, which can solve a range of separation problems.
For preparative SFC, YMC has developed special column hardware.
The company's SFC columns are available in a number of lengths with 20mm, 30mm or 50mm ID.
