Cellexus, a developer of single-use bioreactors and cell-based technologies for biopharmaceutical research and production, has launched the Cellmaker Plus, a single-use, disposable bioreactor system.
The company designed the Cellmaker Plus system specifically for the efficient growth of a range of cell types, including E.coli, pichia, algae and bacteriophage, as well as the more challenging mammalian and insect cells.
The single-use bioreactor system, which will be available with both eight- and 50-litre capacities, incorporates a range of new technologies designed to improve processes and to speed up setup times.
It includes a patented air dispersion system to effectively aerate and mix the cell culture and features a modular control system that is flexible and adaptable and can be configured to satisfy the needs of the application.
The Cellmaker Plus uses Cellexusbags, which are single-use, disposable cell culture bags that allow fast setup times and that eliminate lengthy cleaning protocols.
Whereas other disposable systems require shakers, rockers, rollers or large environmental chambers, the Cellmaker Plus employs proprietary airlift technology to mix, aerate and maintain cell suspension.
This system is simple, scalable and inexpensive to use, according to the company.
The Cellmaker Plus controller enables the precise management of temperature (from 15C to 45C), controls the flow and mix of sparge gas and provides the monitoring and control of pH and dissolved oxygen (DO).
The accurate control of these parameters enables the optimisation of culture growth and the improved expression levels of soluble protein.
'This new system includes all the modularity to enable an oxygen generation capability and the addition of DO and pH sensor options to enable use with the broadest range of cell types depending on users' needs,' said Paul Stubbings, chief operating officer of Cellexus.
