Biotage, a supplier of tools and technology for medicinal and analytical chemistry, has announced the launch of the Isolera ELSD-1080 evaporative light-scattering detector for flash purification.
With the addition of the ELSD-1080, Biotage now provides a flash purification solution for nearly every compound type including semi-volatile UV transparent as well as UV-absorbing compounds.
The ELSD-1080 is a detector accessory designed for use with Biotage Isolera flash purification systems.
The detector vaporizes a portion of the flash cartridge effluent and is able to detect the particles left.
It enables fractionation of compound classes with little or no UV or visible light absorption such as lipids, terpenes, carbohydrates and steroids, expanding the use of Isolera flash purification systems.
Sub-ambient evaporation provides detection capability for semi-volatile compounds with operation at temperatures as low as 10C and up to 80C.
The detector integrates blue LED technology and short wavelength for improved accuracy.
It has a claimed accuracy of +/-2 per cent for reliable results and its high sensitivity provides good responses for semi-volatile compounds.
The device is portable and compatible; it operates with analytical HPLC systems other than Biotage models.
Independent temperature controls for both nebuliser and evaporator provide optimisation capability for normal-phase and reversed-phase solvent systems.
Isolera flash purification systems have a TLC-to-gradient feature that automatically creates elution gradients and suggests cartridge and sample size.
Users can collect fractions using two wavelengths, adjust the flow rate from one to 200ml/min as needed and use up to four solvents in a single gradient, for maximum purity and yield.
Isolera is available in a single-cartridge base model, the Isolera One, and a four-cartridge configuration, the Isolera Four, which is suitable for multi-user or high-throughput laboratories.
All Isolera systems now include Gradient Optimization (GO) technology, which is said to reduce solvent use up to 60 per cent.
