Sigma Aldrich's genetically modified reporter cell lines, based on Compozr zinc finger nuclease (ZFN) technology, has been awarded silver in 'The Scientist's' Top 10 Innovations for 2010.
The genetically modified mammalian cell lines are suitable for use in furthering fundamental understanding of cell biology and accelerating cell-based research.
The proprietary ZFN technology allows precise insertion, substitution or deletion of genes of interest.
The Compozr technology has been harnessed to create a range of genetically modified reporter cell lines, as well as specific isogenic lines initially designed to advance colorectal and breast cancer research.
The first Compozr cellular reporter cell lines were launched in November 2010, and have been optimised for live cell imaging applications.
Incorporating fluorescent tags at endogenous loci of the genes of interest, these offerings avoid the additional stresses and potential toxicity issues associated with protein over-expression in live cells, as well as eliminating the need for tedious staining procedures.
