AB Sciex has introduced Selexion, which it claims is the first differential ion mobility separation technology to deliver high selectivity based on the shape of the molecule.
Current approaches to optimising selectivity are limited to the fragmentation patterns of the individual compounds and chromatographic conditions.
Often these parameters do not provide enough selectivity to eliminate or separate isobaric interferences, or to reduce high background noise in complex samples.
To address this challenge, AB Sciex developed the Selexion technology, which is said to improve selectivity and performance for any application requiring the separation of isobaric species, isolation of challenging co-eluting contaminants and elimination of high background noise.
The company said Selexion is suitable for assays with contaminants that are difficult to separate, such as in the pharmaceutical, contract research, food safety, environmental testing and therapeutic drug monitoring industries.
These assays commonly require a fast, reproducible and easy-to-use approach to enhance the selectivity of LC/MS/MS separations without compromising sensitivity.
The DMS technology is said to improve data quality and accelerate sample preparation procedures.
It possesses day-to-day reproducibility, robustness and ease of use, while delivering an additional dimension of selectivity for sensitive quantitative and qualitative analyses, within a UHPLC timescale and over multiple MRMs (multiple reaction monitoring).
DMS technology works with the AB Sciex Triplequad 5500 and AB Sciex Qtrap 5500 spectrometers.
The Triplequad 5500 system is said to deliver accurate quantitative results at fast scan speeds to identify the greatest number of target analytes at the lowest concentrations in complex samples.
The Qtrap 5500 system is a mass spectrometer that integrates triple quadrupole capabilities with linear ion trap technology called Linear Accelerator Trap.
This combination results in a system that integrates sensitivity and multiple dimensions of selectivity for both quantitative and qualitative analysis.
