GE Healthcare Life Sciences has launched Capto Core 700 chromatography medium for viruses and other large biomolecules.
The company describes the product as a high productivity alternative to group separation for intermediate purification and polishing.
Productivity is improved with up to 100-fold greater sample loadings and significantly higher flow rates.
The Capto Core 700 medium employs core bead technology, with a ligand-activated core and inactive outer layer.
The inactive outer layer excludes large molecules (Mr 700 000 [700 kDa] and above) from entering the beads which can subsequently be collected in the column flowthrough.
Smaller impurities bind to the ligands, which are both hydrophobic and positively charged, resulting in a highly efficient multimodal binding of various contaminants small enough to enter the core.
Capto Core 700 is also available as a bulk medium in a range of pack sizes from lab scale to production-scale.
