A 5-clone cocktail provides consistency for studying individual gene products.
Beneficially the new 5-Clone kit offers excellent consistency meaning the severity of arthritis induced now directly correlates to the dose of monoclonal antibody cocktail, and more severe and consistent arthritis can be induced by increasing the dose of monoclonal antibody cocktail.
Unlike the original CIA model, the new 5-Clone CIAA model is broadly applicable and can induce arthritis in almost all strains of mice.
This model is ideal for studying the pathological role of individual gene products, cytokines, as well as screening anti-inflammatory agents, without influences of complete or incomplete Freund’s adjuvant.
Features overview:
- CIAA produces faster results
- CIA resistant in almost all strains of mice
- Direct correlation to the dose of monoclonal antibody cocktail
