This video demonstrates the advantages of conducting enantioselective ?-aminoxylation reactions under continuous-flow conditions.
The application of polystyrene-immobilised proline-based catalysts in packed-bed reactors for the continuous-flow, direct, enantioselective ?-aminoxylation of aldehydes is described within the accompanying note.
Monitoring of the reaction by in-situ IR spectroscopy allows for the simplified optimisation of reaction conditions and flow rate.
The system allows the preparation of a series of ?-aminoxy alcohols, after a reductive workup, with optical purity and an effective catalyst loading of ca. 2.5% working at residence times of ca. 5 min.
The paper describes a continuous-flow reaction conducted using a Syrris Asia flow chemistry system, and can be viewed in the link above.
