The MagSi-DNA cleanFIX from Amsbio is designed to purify DNA fragments, removing unwanted side products and reagents.
The system is capable of clearing single nucleotides, terminator dyes, primers and primer dimers, enzymes, buffers and salts.
Across a broad spectrum on genomics applications, purification of DNA fragments is required to prevent downstream interference with analysis methods.
Purification of PCR reactions often requires removal of dNTPs, primers, enzymes, salt by-products and various additives.
Historically, these protocols have involved different sample types, different volumes and often multiple washing and centrifugation steps.
Amsbio has stated that its MagSi-DNA cleanFIX platform enables a combination of PCR clean-up and dye terminator removal from sequence reaction mixes with a single product.
The kit uses magnetic silica bead technology, and can be automated because no columns or centrifugation steps are involved.
Furthermore, the kit utilses a “Bind, Wash & Elute” procedure common to magnetic particle purification protocols.