Sygnature Discovery has been using an Asynt DrySyn SnowStorm system to perform low traditionally difficult low temperature reactions.
The Asynt DrySyn SnowStorm offers a solution to laboratories undertaking low temperature reaction chemistries.
Available in a choice of configurations, the system provides controlled cooling and heating for sub-ambient parallel chemistry without the need for jacketed reaction vessels, or ice baths.
Operating with a suitable chiller/circulator, it provides accurate, stable temperature control down to -50 °C and up to 150 °C.
Geraint Jones, associate director of chemistry at Sygnature Discovery says: “Being able to maintain a sub-ambient temperature sometimes for significant periods is really important for reaction reproducibility.
“The DrySyn SnowStorm connects to an external chiller unit and holds temperatures at a set point for as long as is required. Setting temperature ramping profiles is also possible, which is important in optimisation studies and is a real added benefit to us.”
Meanwhile, Mark Mills, senior research chemist at Sygnature Discovery adds: “We purchased the DrySyn SnowStorm to achieve tight temperature control (at -20°C) for a reaction involving a stereoselective cyclisation. If we had not been able to maintain this temperature for a sustained period, racemisation could have occurred.
“We selected the Asynt equipment because it integrated well into our way of working and allowed the use of round-bottomed flasks in a variety of sizes, thereby providing the flexibility to conduct small to medium scale reactions.”
