Range of chromatography media enables fast, efficient and cost-effective large-scale protein purification of high expression feeds
GE Healthcare, a combination of the former Amersham and GE Medical Systems, announces the launch of Capto Q, the first in a new family of chromatography media.
The Capto Q medium for protein purification in downstream processing meets the growing need in the biopharmaceutical market to process large feed volumes with high protein expression levels.
Capto Q is said to be ideal for use in the capture and intermediate purification of high expression and high volume feeds.
The highly rigid matrix allows a wider working range of flow velocities, bed heights and sample viscosities, all of which positively influence processing costs.
High flow velocities increase volume throughput and reduce process time; longer bed heights eliminate the need for large equipment and keep footprints small; and high-flow processing of viscous samples means less dilution and shorter cycle times. "The combination of the strong ion exchanger and the chemically modified matrix will make Capto Q the obvious choice for researchers performing large-scale protein purification," said Mats Grahn, vice president of product management, protein separations at GE Healthcare.
"The high dynamic binding capabilities at high flow rates allow fast purification of large volume high expression feeds, enabling increased throughput in downstream processing".
The high capacity strong quaternary ammonium (Q) ion exchanger, coupled to a chemically modified high-flow agarose matrix, enables high flow rates at manufacturing-scale under low pressure conditions, thereby providing a fast, efficient and cost effective purification process.
Capto Q is also available in prepacked HiTrap column format for added convenience during the screening process.
