Advanced quadrupole ion trap mass spectrometer product line promises sensitivity and ultra-fast acquisition to set new standards for proteomics and metabolomics
At the 2004 Pittsburgh Conference in Chicago, Bruker Daltonics announced a new ion trap mass spectrometer product line, including the new top-of-the-line HCTplus, the latest high capacity trap with significantly enhanced ion transmission, storage and detection capabilities.
Ten years after pioneering its first commercial ESI ion trap, the Esquire in 1994, the company showcases three new ion trap products, the Esquire4000t, Esquire6000t, and HCTplus, in addition to the existing HCT, which was introduced one year ago.
The robust and sensitive Esquire4000 and Esquire6000 ion trap systems provide standard and high-performance MS and MS(n) for liquid chromatography mass spectrometry applications in drug discovery, drug development, academic research, and general LC/MS/MS.
Bundled with application- specific software packages these LC-ESI/MS(n) systems are highly productive tools for demanding applications like fast screening of natural products, structural elucidation, quality control, mass-directed auto-purification, LC/NMR/MS/MS, etc The Esquire4000 features an M/Z range up to 4000, while the Esquire6000 features an M/Z range up to 6000.
Both systems are at least twice as sensitive as the Esquire2000 and Esquire3000plus, which they replace.
As the latest innovation in quadrupole high capacity traps, Bruker Daltonics believes the HCTplus features the overall highest sensitivity in full scan MS and MS/MS for all ion traps, in combination with ultra-high acquisition speed, optimal spectral information content, and exceptional in-scan dynamic range.
These unique attributes translate directly into information-rich LC/MS(n) runs, important for the identification and characterisation of proteins/peptides and drug metabolites. Powered by Compass software, both the HCT and the HCTplus are fully integrated into the Proteineer solutions for 2D-gel based or (multi-)LC expression proteomics methods.
The HCTplus is four times more sensitive than the existing HCT, and is available at a price surcharge.
Jochen Franzen, managing director for Bruker Daltonik GmbH, said: "As the HCTplus acquires even more high-quality data from low concentration biological samples, it enables high- information content LC/MS(n) analysis, which is optimal to feed efficient bioinformatics platforms like Proteinscape.
"We strongly believe the new HCTplus adds significant value to customers performing challenging research work in expression proteomics, metabolite studies and biomarker discovery".
For pharmaceutical customers, all Esquire and HCT systems offers software tools to support customers in achieving 21 CFR part 11 compliance.
Bruker Daltonics provides optional IQ, OQ and PV services to FDA-regulated customers.
