Novel platform for bottom-up and shot-gun proteomics promises resolution and mass accuracy greatly surpassing alternative hybrid ion trap-FTMS combinations
At the 2004 Pittsburgh Conference in Chicago, Bruker Daltonics announced its novel Apex-QE 7 Tesla hybrid Q-q-FTMS proteomics platform for bottom-up and shot-gun proteomics.
The Apex-QE is fully integrated with the novel Top-Pro technology for the most sensitive top-down proteomics capabilities in FTMS.
The new Apex-QE 7T is an exceptionally easy-to-use Q-q-FTMS system for ultra-high performance proteomics mass spectrometry.
Its FTMS/MS sensitivity, resolution and mass accuracy greatly surpasses alternative hybrid ion trap-FTMS combinations that mostly just operate as an ion trap in MS/MS mode without fully using the benefits of ultra-high resolution and superb mass accuracy in FTMS/MS.
The Apex-QE delivers ultra-high resolution data for all measurements for consistency across large sample sets and automated overnight runs.
The Apex-QE now operates under Bruker Daltonics's integrated Compass software environment for easy operation in multi-instrument laboratories, and with what is described as the most comprehensive bioinformatics analysis software suite in the industry.
Running this powerful Q-q-FTMS system is now as easy as running a Bruker Daltonics ion trap for LC-ESI-MS(n) proteomics experiments.
At 7 Tesla, it has an affordable list price of $750,000, which makes it accessible for many proteomics laboratories.
In addition, the Apex-QE combines the robust CID capabilities of the Q-q-front end with the unique and powerful new Top-Pro technology for top-down proteomics. Top-Pro integrates the uniquely sensitive selective ion enrichment capabilities of the Q-q- front-end with powerful electron capture dissociation (ECD), and our BioTools software for top-down de novo protein sequencing and the discovery of post-translational modifications (PTM).
The Apex-QE system can be an integral module of Proteineer solution for high-success expression proteomics, including Proteineer solutions for 2D-gel based or (multi-)LC proteomics methods.
