Arrays can be used to study transcription factor activation in a variety of biological processes including cell proliferation, differentiation, transformation and apoptosis
Cambridge BioScience's range of TranSignal arrays now includes the TranSignal protein/DNA arrays I and II.
These transcriptional regulation assays can be combined to screen a total of 150 unique transcription factors simultaneously.
This allows determination of active transcription factors in a cell or tissue sample in a single experiment.
Interactions between multiple transcription factors can also be analysed.
TranSignal protein/DNA arrays simplify the functional analysis of eukaryotic transcription factor.
They have significant advantages over cumbersome gel motility-shift assays which only allow characterisation of a single transcription factors.
The assays are safe, requiring no radiation, and are highly sensitive thanks to improved HRP-based chemiluminescence.
The TranSignal procedure is simple and straightforward.
Each array is spotted with 54-96 different consensus-binding sequences, each corresponding to a specific, highly characterised transcription factor.
TranSignal arrays can be used to study transcription factor activation in a variety of biological processes including cell proliferation, differentiation, transformation and apoptosis.
