A collaborative programme on the proteomics of aging focuses on mitochondrial oxidative stress and the role of mitochondrial dysfunction in degenerative neurological disease
Proteome Systems and the Buck Institute for Age Research have announced a collaborative programme on the proteomics of aging, focusing on mitochondria.
Mary Lopez, VP research and development at Proteome, said, "proteomic analysis of brain mitochondria will allow us to identify the proteins, or their modifications, that are associated with oxidative stress and aging.
Beginning to understand the key molecules will give insight into aging and help guide studies on age-related disease".
"Proteomic profiling using mouse models for aging and neurological disease will enable us to track the molecular changes that occur at the functional level in cells", said Simon Melov, one of the founding faculty at the Buck Institute and key collaborator on this program, which also includes Julie Andersen and David Nicholls.
"The combination of Proteome Systems' advanced technologies and intellectual capacity in proteomics, coupled with our extensive understanding of aging processes, will accelerate the identification of anti-aging drug targets.", said Dr Melov.
Keith Williams, CEO of Proteome Systems, said "Proteome Systems has teamed with the Buck Institute because we like the energy and focus of this group in their dedication to age research.
Our strategy is to collaborate with the best research scientists internationally for our discovery programs. It is very exciting for Proteome Systems to have an opportunity to work with Simon Melov, who we regard as one of the top researchers on aging in the world." Dale Bredesen, CEO, Buck Institute for Age Research said, "We are delighted to partner with Proteome Systems.
As the first freestanding institute devoted to basic research on aging and age-associated diseases, we hope to help shape the future of aging research, and to do this we need to work with groups that have cutting edge technology and creative people to facilitate our research programs.
It is clear to us that Proteome Systems has the vanguard technology and broad experience base in proteomics that we are seeking".
