Novel hybrid liquid chromatograph/mass spectrometer is intended for biomarker discovery, metabolite identification, and proteomics research
Shimadzu Scientific Instruments has introduced the LCMS-IT-Tof liquid chromatograph/mass spectrometer, a novel hybrid mass spectrometer for biomarker discovery, metabolite identification and proteomics research.
Coupling atmospheric pressure ionisation with Ion-Trap (IT) and Time-of-Flight (Tof) technologies, the LCMS-IT-Tof delivers high mass accuracy and high mass resolution (10,000 at 1000m/z) independent of MS mode.
Shimadzu's LCMS-IT-TOF has been designed to maximise sensitivity and selectivity by optimising the ion transport to the Tof analyser and redefining the capability of the quadrupole ion trap.
The ion trap is not only used to focus ions before ejection into the of, but it also supports fragmentation, MSn analysis and a high precursor ion selection (resolution 1000 at 1000m/z).
A high precursor ion selection allows specific ions to be isolated for further fragmentation, simplifying MS/MS data interpretation and enhancing the selectivity of detection, particularly from complex matrices.
A fast polarity switching speed (100ms to switch between positive and negative ionisation), combined with compressed ion injection (patented), ballistic ion extraction (patent pending), and dual-stage reflectron (patent pending) technology, creates what Shimadzu calls a true benchmark for biomarker discovery, metabolite identification, and proteomics research.
