Polymeric resin for reversed phase chromatography claims all the advantages of premium silica and polymeric media including selectivity, yield, capacity, pH stability, and CIP/SIP compatibility
Amberchrom HPR10 reversed phase chromatographic resin reduces operating costs and improves process economics through its unique 10u monosized polymeric resin which claims all the advantages of both premium silica and polymeric media including: selectivity, high yield and capacity, full pH stability, full CIP/SIP compatibility and stability up to 100 bar.
Amberchrom HPR10 has been optimised to deliver high capacity for peptides, small proteins and other biomolecules, says Rohm and Haas.
Previously, silica was the preferred media for final polishing steps and polymeric resins were mostly used for capture and the intermediate step.
Amberchrom HPR10 resin, with its very rigid polymeric matrix and a mechanical resistance close to that of silica, can perform under pressures as high as 100 bar and provide improved selectivity and purity.
The high loading capabilities of the Amberchrom HPR10 resin enable economical, large scale operation for critical products such as therapeutic peptides.
Amberchrom HPR10 resin can withstand rigorous clean-in-place (CIP) protocols.
It allows the use of 1N NaOH for CIP in the final polishing step, thus saving processing and validation time.
Moreover, Amberchrom HPR10 resin's extended lifetime contributes to reduce total operating costs by decreasing the plant shutdown time and overall chromatographic media costs.
Seamlessly scalable, Amberchrom HPR10 resin is available in bulk from analytical to industrial quantities, but also as Amberchrom Profile HPR10 RP HPLC columns with a 4.6, 10, 20, 50 or 70mm diameter.
