Second-generation digital receiver (2G-DR) technology on Avance II series offers compelling performance advantages to NMR researchers
Bruker BioSpin announced the introduction of its next-generation NMR spectrometer series, called Avance II, at Pittcon 2005.
The Avance II incorporates second-generation (2G) digital receiver (DR) technology for a significant further improvement in NMR detection fidelity.
This 2G-DR technology will be beneficial for demanding NMR experiments in solid-state research, synthetic polymer analysis, trace analysis, LC-NMR, MR imaging and structural biology, especially when using Bruker BioSpin's highest sensitivity CryoProbes.
Bruker BioSpin pioneered first-generation (1G) digital receiver technology in the 1990s as part of its NMR digitalization initiative with the introduction of the novel Avance platform: for the first time, the Avance featured innovative digital receiver technology for over-sampling, digital filtering and digital quadrature detection, now all de facto standards in NMR.
The new 2G-DR technology introduced at Pittcon 2005 on the new Avance II platform represents a further dramatic improvement in digital receiver technical capabilities: more than four-fold higher digital resolution and unsurpassed dynamic range, even faster digitization rates and an order of magnitude faster over-sampling, more than an order of magnitude increase in digital filtering bandwidth, an order of magnitude increase in digital quadrature detection (DQD) bandwidth, and a single receiver for even the most demanding liquids, solids and imaging applications.
In terms of chemical and biological applications, researchers using the Avance II will benefit from significant performance increases in many areas of NMR spectroscopy and imaging: unsurpassed inter-modulation suppression and flat baselines in high-dynamic range samples with many intense signals, eg in synthetic polymer analysis, flow-NMR and LC-NMR applications, or in trace analysis in the presence of other strong signals, enhanced digital filtering now also available for large spectral widths so far unheard of in NMR, eg for highest quality data in research on paramagnetic proteins, liquid crystals, solid-state wide-line NMR, ultra-fast MR imaging experiments, as well as high-resolution carbon (13C) and fluorine (19F) spectroscopy, enhanced DQD capabilities for large sweep widths, further reducing even low-level artifacts in NMR liquids, solids and MR imaging applications, enhanced sensitivity for weak signals in samples with very strong signals, thus further boosting the outstanding sensitivity of the new Avance II platform.
This latest feature is of increasing importance for any NMR system equipped with CryoProbe technology which requires highest receiver dynamic range.
"The new 2G-DR technology is the logical continuation of the major technological improvements that we have introduced over time on our Avance spectrometer series," explained Oskar Schett, managing director of Bruker BioSpin in Switzerland.
"The entire NMR community can benefit from the added performance and functionality of the new Avance II spectrometer generation".
Werner Maas, Bruker BioSpin's vice president of R+D, commented: "For solid-state NMR spectroscopy, the new Avance II is somewhat of a solids dream machine, as it now provides all the benefits of digital filtering, digital quadrature detection, etc, that have previously been available primarily for liquids NMR, also to the solids NMR community.
"We believe that solid-state NMR of bio-solids such as membrane proteins, or of advanced materials, will be of increasing importance in the future."
