Thermo Scientific HCS Studio cell analysis software for more productive High Content Screening

High Content Screening (HCS) also known as High Content Analysis (HCA), image cytometry, quantitative cell analysis or automated cell analysis, is an automated method of cell analysis. Used primarily in biological research and drug discovery HCS combines fluorescent microscopy, automated cell calculations, phenotyping and image processing algorithms and informatics tools to identify and assess substances that can alter the phenotype of a cell.

ThermoFisher Scientific are innovators in the field and their Thermo ScientificTM Cellular Imaging and Analysis product line (previously called ‘Cellomics’) provides a full complement of hardware, analysis and control software, as well as informatics database tools to fully implement a high content screening program in any research laboratory.

Their Thermo Scientific HCS Studio Cell Analysis Software balances flexibility with ease-of-use combining intuitive interfaces, intelligent design and powerful image analysis tools to enable advanced interpretation of dynamic event measurements at all levels, from cell to field.

Guided workflows with visual feedback allow for assay protocol setup, image acquisition, analysis, and scanning, and simultaneous data acquisition and analysis saves time. The simple and straightforward task-oriented approach to image algorithm development means that new users face minimal challenges and the HCS StudioTM Cell Analysis Software allows them to commence with more than 30 pre-established assays all of which can be optimised to cell line and particular phenotype.

Thanks to Thermo Scientific’s intuitive approach it is easy to build your own assay from scratch with their flexible software tools. Instant feedback means the user can control hundreds of options including background correction, object segmentation, spot/granular detection, region of interests, sensitivity of detection, projected image format, contrast of images and phenotypic gating.

For more complex assays HCS Studio Cell Analysis Software scales seamlessly thanks to a raft of algorithmic, visualisation, and online help tools that both simplify and save time. By ensuring only a statistically significant number of cells are captured, less time is spent scanning unnecessarily.

Thermo Scientific’s HCS Studio Cell Analysis Software makes quantitative cell analysis a viable option by reducing the complexity and time investment of assay development, thereby allowing users to address multiple biological phenotypes to discover more about cells and their functions.