Shimadzu’s New Nexera Preparative Supercritical Fluid Chromatography System
17 Oct 2019
Shimadzu Scientific Instruments (SSI), in partnership with the Enabling Technologies Consortium (ETC), announces the release of the next generation Nexera Preparative Supercritical Fluid Chromatography System, providing the pharmaceutical industry with reliable high-performance semi-prep purification.
The system is part of SSI’s Nexera UC platform, which accommodates a wide variety of analyses and purifications. The platform is based around the company’s ultra-high-performance liquid chromatograph. Each UC semi-prep system is configurable to user specifications in order to optimally perform the desired purification function, including chiral or achiral purifications, single injections, stacked injections and fraction collections from several microlitres to litres.
Designed to reduce the need for costly and hazardous solvents used in normal phase prep LC, the complete system is designed to shorten purification run time and dry down time. Innovative technologies include a flexible format combination injector/fraction collector, CO2 pump with integrated chiller that requires less lab space and allows for benchtop use, a novel gas-liquid separator (GLS) design to ensure high recovery and low carryover, and easy-to-use preparative software to streamline operations.
A newly designed gas-liquid separator realises a higher recovery ratio and lower carryover than earlier SFC systems. The total size of the recovery system has been reduces and allows for easy rinsing compared to earlier cyclone-style or centrifugal-type GLS systems.
“The Nexera prep SFC system is an improved purification instrumentation that meets the specifications and requirements of SFC users across the pharmaceutical industry,” said Mirlinda Biba, PhD, principal scientist, Merck & Co. Inc., and ETC lead for the project. “This new-generation system provides improved hardware and software features that answer the pharmaceutical industry’s demand for an efficient and robust prep SFC system.”
“Working with the Enabling Technologies Consortium and hearing the voice of the pharmaceutical industry has been incredibly valuable learning experiences for us at Shimadzu,” said Patrick Fromal, VP sales, Shimadzu Scientific Instruments. “Their insight into what’s truly needed by the industry drove this project forward, and we are very grateful for the opportunity to work with such an amazing team.”
Find more information about the Nexera Prep SFC System here.