Porvair Sciences has launched Microlute PLR, a 96-well microplate providing effective removal (>99%) of phospholipids and proteins with higher levels of reproducibility from plasma and serum samples, while maintaining maximum recovery of target analytes.
Phospholipid-based matrix effects are a major source of variability and inaccuracy in bioanalytical mass spectrometry (MS) analysis. Popular sample preparation techniques such as protein precipitation, dilute and shoot or liquid-liquid extraction methods may not completely remove phospholipids. Microlute PLR is designed to ensure minimal enhancement or suppression of analyte response by truly eliminating the source of matrix effects and not just masking the problem.
The plate is composed of a solid interconnected network of evenly distributed pores that allow biological fluids to flow smoothly and consistently throughout the active media. This proprietary feature overcomes common channelling and breakthrough issues by enhancing the flow of samples throughout the filter – thereby maximising the recovery of analytes and improving the overall performance of phospholipid removal.
For further information on the Microlute PLR microplate, and details of a comparative testing study, please click here or contact Porvair Sciences on +44-1978-666222 / +1-856-696-3605 / int.sales@porvairsciences.com.
