Cambridge BioScience has introduced a novel range of fatty acid binding protein (FABP) Elisa kits for liver, intestinal, ileal and heart tissues
Highly sensitive measurement of cytosolic FABPs enables early and rapid detection of cell membrane/tissue damage.
In recent studies, liver fatty acid binding proteins (L-FABP) and mannose binding lectin (MBL) have proven to be interesting markers for risk analysis for liver and kidney transplantation respectively.
Cambridge BioScience offers a wide range of Elisa kits and antibodies, developed by HBT, for the detection of FABPs in a variety of species.
L-FABP is a small protein involved in the intracellular transport of long-chain fatty acids in the liver.
Publications on monitoring liver damage via L-FABP are rapidly increasing in number.
A key advantage of L-FABP over other liver damage markers is its fast renal clearance, which results in a shorter half-life and therefore plasma levels more directly reflect damage of the hepatic allograft.
MBL is a member of the collectins that activate the complement pathway.
Kidney transplantation studies show that elevated MLB levels are associated with inferior graft survival.
Further studies on pre-transplant MBL levels and graft function are warranted for future risk stratification prior to kidney transplantation.
Detection of cell damage, by FABP measurement for example, is important in cellular toxicology studies and in various experimental and clinical situations such as myocardial infarction and liver transplantation.
These products are available from Cambridge Bioscience in the UK and Ireland only.
