At the 55th ASMS conference on mass spectrometry, Bruker Daltonics launched its ImagePrep sample preparation device for automated matrix deposition onto tissue slices
Maldi mass imaging of tissue samples with Bruker's Maldi Molecular Imager (for research use only) solution allows colour-coded visualisation of the distribution of peptide or small protein biomarkers, or of drugs and their major metabolites for the direct analysis of molecular distributions in tissue sections.
The new ImagePrep device provides highly reproducible sample preparations for Maldi Imaging in a fully automated, push-button process.
Another unique advantage of ImagePrep is the combination of excellent spectra quality at high image resolution of 50um at the same time.
With the launch of the ImagePrep, Bruker completes its Maldi Molecular Imager solution consisting of autoflex or ultraflex high-performance Maldi-Tof(/Tof) mass spectrometers with smartbeam laser technology and Pan panoramic mass resolution over a broad mass range, plus flexImaging software for data analysis, visualization and statistical analysis of Maldi images, including the proprietary ClassImaging method for the molecular imaging equivalent of diagnostic multimarker panels.
Michael Schubert, executive vice president of Bruker Daltonics, commented: "With the novel ImagePrep technology of vibrational vaporisation, we have overcome the lack of robustness and the limited spatial resolution of older matrix deposition technologies.
"Moreover, ImagePrep is unique in that it utilises an optical sensor to monitor light scattered by the matrix layer to greatly enhance reproducibility and quality control in Maldi tissue preparations.
"This QC process leads to the most reliable and reproducible push-button sample preparation available for high-information content, high resolution Maldi Imaging today.
"ImagePrep is an essential tool for scientists and clinicians to use Maldi imaging as a routine research technology.
"The release of our ImagePrep product emphasises Bruker Daltonics's expertise and commitment to develop advanced clinical research solutions based on mass spectrometry."
