These peptides belong to the family of anti-microbial peptides which form part of the host's important innate immunity mechanism
Cathelicidins are cationic peptides that have broad-range antimicrobial activity.
In humans, cathelicidins and defensins are expressed in immune cells and at epithelial surfaces.
hCAP18, human cationic antimicrobial protein, with a MW of 18 kD, is the only cathelicidin gene found in humans.
The N-terminus of this protein consists of a cathelin-like region (similar to the other members of the cathelicidin family) and a C-terminal termed LL-37.6-7 An amphipathic alpha-helical peptide, LL-37 plays an important role in the first line of defense against local infection and systemic invasion of pathogens at sites of inflammation and wounds.
Cytotoxic to both bacterial and normal eukaryotic cells, LL-37 is significantly resistant to proteolytic degradation in solution.
Offering one of the world's largest collections of catalogue peptides, AnaSpec introduces a wide range of structurally-diverse cathelicidin peptides, some of which have not been commercially available until now.
