This week AnaSpec, a world leader in custom and catalogue peptides, introduced eleven (11) new peptides
[dAla2,Cys4]Deltorphin C- Cat# 62680.
This deltorphin C (or deltorphin 1) peptide modification is a selective agonist at the supraspinal opioid delta-1 receptor subtype in mouse.
It was evaluated in an anti-nociceptive assay after ICV administration to mice.
It was shown to produce dose-related anti-nociceptive effects.
Sequence: YaFCVVG-NH2.
Deltorphin A- Cat# 62682.
Deltorphin A peptide was isolated from skin extracts of the South American frog, Phyllomedusa sauvagei.
Deltorphin A is a potent and selective agonist for the delta-opioid receptor.
Sequence: YmFHLMD-NH2.
CMV EP 88, Cytomegalovirus Early Protein pp89 Derivative, YPHFMPTNL,- Cat# 62781.
This peptide is processed from the immediate early protein pp89 of mouse cytomegalovirus (CMV).
It is presented to CD8+ T lymphocytes by the H-2 Ld molecule.
Infection of mice with murine CMV leads to CD8 cell responses to this immunodominant epitope.
This peptide was employed in vaccines development.
Sequence: YPHFMPTNL.
CHK1tide, 5-TAMRA labeled- Cat# 62807-1.
This is checkpoint kinase CHK1 substrate labeled with TAMRA.
CHK1 is an evolutionarily conserved protein kinase that has been implicated in cell cycle checkpoint control in lower eukaryotes.
Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppression.
Sequence: TAMRA-ALKLVRYPSFVITAK-NH2.
CHK1tide, 5-TAMRA labeled- Cat# 62807-5.
This is checkpoint kinase CHK1 substrate labeled with TAMRA.
CHK1 is an evolutionarily conserved protein kinase that has been implicated in cell cycle checkpoint control in lower eukaryotes.
Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppression.
Sequence: TAMRA-ALKLVRYPSFVITAK-NH2.
CHK1tide, FAM labeled- Cat# 62806-1.
This is checkpoint kinase CHK1 substrate labeled with 5-FAM.
CHK1 is an evolutionarily conserved protein kinase that has been implicated in cell cycle checkpoint control in lower eukaryotes.
Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppression.
Sequence: FAM-ALKLVRYPSFVITAK-NH2.
CHK1tide, FAM labeled- Cat# 62806-5.
This is checkpoint kinase CHK1 substrate labeled with 5-FAM.
CHK1 is an evolutionarily conserved protein kinase that has been implicated in cell cycle checkpoint control in lower eukaryotes.
Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppression.
Sequence: FAM-ALKLVRYPSFVITAK-NH2.
Neurotensin- Cat# 62677.
This 13 amino acid peptide was first isolated from bovine hypothalamus and was named from its neuronal localization.
It was detected in the central nervous system (CNS) and peripheral tissues mainly in the gastrointestinal tract.
This bioactive form of neurotensin post-translationally modified at a Glu residue was isolated from porcine intestine.
In the CNS, neurotensin has dual function of neuromodulator of dopamine transmission and of anterior pituitary hormone secretion.
It also shows potent hypothermic and analgesic effects in the brain.
Neurotensin has been implicated in the pathophysiology of schizophrenia, Huntington, and Parkinson diseases.
Sequence: QLYENKPRRPYIL.
Leucokinin II, Myokinin II, Anopheles- Cat# 62768.
This peptide belongs to the Anopheles leucokinin II.
Insect leucokinins elicit potent diuretic effects on the Malpighian tubules of insects, and contraction of the hindgut hence the alternative term "myokinin." This is the shortest of all three Anopheles leucokinins, with the sequence identical to culekinin I, and Aedes leucokinin II.
Sequence: NPFHSWG-NH2.
MAGE-3 (114-127)- Cat# 62702.
This is amino acids 114 to 127 fragment of the MAGE-3 protein.
Among the MAGE genes, MAGE-3 is one of the most frequently expressed in tumors.
For instance, it is expressed in 76% of metastatic melanomas.
This peptide binds to HLA molecules and hence could be a target antigen for an antitumor CTL response.
Sequence: AELVHFLLLKYRAR.
MAGE-3 (121-134)- Cat# 62701.
This is amino acids 121 to 134 fragment of the MAGE-3 protein.
MAGE-type genes are expressed by many tumors of different histological types and not by normal cells, except for male germline cells.
Therefore, the antigens encoded by MAGE-type genes are strictly tumor specific and common to many tumors.
This peptide is presented by the HLA-DR13 molecule which is expressed in 20% of XCaucasians.
Sequence: LLKYRAREPVTKAE.
